Atroposelective Total Synthesis of the Fourfold ortho ‐Substituted Naphthyltetrahydroisoquinoline Biaryl O , N ‐Dimethylhamatine
نویسندگان
چکیده
منابع مشابه
Pushing the limits of steric demand around a biaryl axis: synthesis of tetra-ortho-substituted biaryl naphthalenes.
The synthesis of tetra-ortho-substituted biaryl naphthalenes, including examples bearing multiple ortho-isopropyl groups, has been developed via a catalytic rearrangement process.
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J (H .H)=0 .9Hz . lH, 10a-H), 5.75 (ddd, J(H,H)=17.0Hz, J ( H , H ) = 10.0 Hz. J (H,H) = 8.0Hz, 1 H, 9-H), 7.02 (AABB, analyzed as AB, Avnn = 54.0 Hr, J (H.H) = 9.0 Hz, 4 H, Ph-H), 7.54 (m. 1 H, 2-H). "C NMR (50.3 MHz, C,D,CI,, 100 "C): b =19.80* (C-6). 27.71 * (C-5). 30.65 (C-71, 35.96 (C-4a). 40.26 (C-4), 41.24 (C-8), 50.45 (OCH,), 51.57 (OCH,), 55.45 (Ph-OCH,). 58.87 (C-l'), 59.73 (C-8 a), 9...
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ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2019
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.201903832